• K2D3™ complex supports optimal calcium absorption and uptake by bones1,3
• Helps bone density and protects against fractures3,4,5
• Helps to lower the risk of osteoporosis1
• Safe for use during pregnancy and breastfeeding1
• Food for growing bones and healthy teeth in children6
• One-a-day1
Vitamin D3 increases calcium absorption in the gut and stimulates the production of osteocalcin in bone.7,8
Osteocalcin helps to take calcium from the blood and bind it to the bone matrix, but it is inactive when newly made.3
Vitamin K2 activates osteocalcin to bind calcium to bone and increase bone strength.3
In a study of post-menopausal women, those who took vitamin K2 and D3 together showed a marked increase in bone mass compared to women who took either Vitamin K2 or Vitamin D3 alone.4 The study concluded that continuous intake of a combination of Vitamin K2D3 increases bone mass in post-menopausal women.4
Various minerals play a role in bone strength:
Copper helps with the cross-linking of collagen in bone for improved bone strength9
Magnesium is involved in bone formation and metabolism of vitamin D10
Manganese can increase bone mineral density and bone formation11
Zinc plays a role in protein and DNA synthesis and supports normal growth12
1. RADICAL® TABLETS patient information leaflet.
2. Amod A, Ascot-Evans B, Brown S, et al. National Osteoporosis Foundation of South Africa Guidelines 2017. JEMDSA 2017;22(1 Suppl. 1):1-180.
3. Maresz K. Proper calcium use: vitamin K2 as a promoter of bone and cardiovascular health. Integrative Medicine 2015;14(1):34-39.
4. Ushiroyama T, Ikeda A, Ueki M. Effect of continuous combined therapy with vitamin K2 and vitamin D3 on bone mineral density and coagulofibrinolysis function in postmenopausal women. Maturitas 41;2002:211–221.
5. Calcium Fact Sheet for Professionals. National Institutes of Health. Available from: https://ods.od.nih.gov/factsheets/calcium-HealthProfessional/.
Accessed 28 Feb 2022.
6. Kozioł-Kozakowska A, Maresz K. The Impact of Vitamin K2 (Menaquionones) in Children’s Health and Diseases: A Review of the Literature. Children 2022;9(78).
https://doi.org/10.3390/children9010078.
7. calcium fact sheet for Health Professionals. National Institutes of Health. Available from: https://ods.od.nih.gov/factsheets/calcium-HealthProfessional/.
Accessed 30 March 2022.
8. Popko J, Karpinski M, Chojnowska S, et al. Decreased levels of circulating carboxylated osteocalcin in children with low energy fractures: a pilot study.
Nutrients 2018;10:374; http://dx.doi.org/10.3390/nu10060734.
9. Saito M, Marumo K. Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus. Osteoporos Int 2010;21:195–214.
10. Magnesium fact sheet for Health Professionals. National Institutes of Health. Available from: https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/.
Accessed 30 March 2022.
11. Manganese fact sheet for Health Professionals. National Institutes of Health. Available from: https://ods.od.nih.gov/factsheets/Manganese-HealthProfessional/.
Accessed 30 March 2022.
12. Zinc fact sheet for Health Professionals. National Institutes of Health. Available from: https://ods.od.nih.gov/factsheets/Zinc-HealthProfessional/.
Accessed 30 March 2022.
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[S0] RADICAL® TABLETS: Per tablet: K2D3™ Complex (70,0 µg) providing: Vit D3 1000 IU & Vit K2 45 µg; Calcium 600 mg; Magnesium 100 mg; Copper 0,5 mg; Manganese 0,5 mg; Zinc 4,35 mg.
[S0] RADICAL® ADULT CHEWS: Per tablet: K2D3™ Complex (70,0 µg) providing: Vit D3 1000 IU & Vit K2 45 µg; Calcium 600 mg; Magnesium 100 mg; Copper 0,5 mg; Manganese 0,5 mg; Zinc 4,35 mg.
[S0] RADICAL® JUNIOR CHEWS: Per tablet: K2D3™ Complex (36,7 µg) providing: Vit D3 268 IU & Vit K2 30 µg; Calcium 300 mg; Magnesium 67 mg; Copper 0,33 mg; Manganese 0,33 mg; Zinc 2,92 mg. D.34.12
Complementary Medicines: Health Supplements – Multiple substance formulation. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use. Nativa (Pty) Ltd. www.nativa.co.za.
Customer Tel Number: +27 860 628 482. Customer Care e-mail: health@nativa.co.za. YWRAD001/01.
